Lopinavir Referências | Menu de navegação192725-17-092727EXPT0038883706Droga usada para combater HIV pode servir contra câncer de colo uterinoe

Inibidores da proteaseAntirretrovirais


antirretroviralinibidores de proteaseFDA15 de setembro2000HIVvírus do papiloma humano




















Lopinavir
Alerta sobre risco à saúde

Lopinavir.svg

Nome IUPAC
(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide
Identificadores

Número CAS

192725-17-0

PubChem

92727

DrugBank

EXPT00388

ChemSpider

83706
Propriedades

Fórmula química
C37H48N4O5

Massa molar
628.77 g mol-1
Farmacologia

Via(s) de administração

via oral

Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão
Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Lopinavir é um antirretroviral da família dos inibidores de protease. Foi aprovado pelo FDA em 15 de setembro de 2000. É utilizado no combate ao vírus HIV e estudos apontam que também pode ser utilizada contra o vírus do papiloma humano.
[1]



Referências |



  1. ↑ G1. Droga usada para combater HIV pode servir contra câncer de colo uterino. Acesso em 4 de maio de 2011


















v • e
Antivirais: antirretrovirais usados contra o HIV (J05)

Inibidores de fusão

gp41 (Enfuvirtide) · CCR5 (Maraviroc, Vicriviroc†, PRO 140†) · CD4 (Ibalizumab†)

Inibidores da transcriptase
reversa (RTIs)




Nucleosídeos
Abacavir (ABC)°# · Emtricitabine (FTC)°# · Lamivudina (3TC)°# · Didanosina (ddI)# · Zidovudina (AZT)# · Apricitabine† · Stampidine† · Elvucitabine† · Racivir† · Amdoxovir† · Stavudine (d4T)# · Zalcitabine (ddC)◊Tenofovir°#
Não Nucleosídeos

(1st gen) Efavirenz°# · Nevirapine#  · Loviride◊ · Delavirdine◊ ·
(2nd gen) diarylpyrimidines (Etravirine, Rilpivirine†)  · Lersivirine†
Inibidor da integrase

  • Dolutegravir (DTG)° · Elvitegravir (EVG)°  · Raltegravir (RAL)° · BI 224436† · Globoidnan A (experimental)  · Cabotegravir† · Bictegravir†  · MK-2048†

Inibidores da protease (IP)(Inibidores da 'Maturação')


Atazanavir° · Fosamprenavir° · Lopinavir°# · Darunavir · Nelfinavir# · Ritonavir# · Saquinavir# · Tipranavir · Amprenavir◊ · Indinavir◊# · Bevirimat† · Vivecon†
Fórmulas para combinações
Combivir · Atripla · Trizivir · Truvada · Kaletra · Epzicom
Agentes experimentais








Imunidade genética
TRIM5alpha (gene primata)
Inibidor da transcrição
Antagonista da TAT
Outros
Abzyme · Calanolide A · Ceragenin · Cyanovirin-N · Diarylpyrimidines · Epigallocatechin gallate (EGCG) · Foscarnet · Griffithsin · Hydroxycarbamide · Miltefosine · Portmanteau inhibitors · Seliciclib† · Synergistic enhancers · Tre recombinase · Zinc finger protein transcription factor · KP-1461†
Agentes fracassados
Dexelvucitabine · Capravirine · Emivirine · Lodenosine · Atevirdine · Brecanavir · Aplaviroc
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