SKF-77,434 Referências Menu de navegação104422-04-012411204878338210.1007/BF022494079336305108694061159444810.1007/s0021301007791191966310.1007/s00213-001-0976-z1600021710.1016/j.pbb.2005.06.0061691494810.1097/01.fbp.0000205015.67079.f7

!Páginas que usam predefinições depreciadasAgonistas da dopaminaAlquenos


agonistas parciaisdopaminérgicos
D1estimulantesanorécticoseficáciaSKF-81,2976-Br-APBcocaína































Estrutura química de SKF-77,434

SKF-77,434
Star of life caution.svg Aviso médico


Nome IUPAC (sistemática)

3-alilo-1-fenil-1,2,4,5-tetraidro-3-benzazepino-7,8-diol

Identificadores

CAS

104422-04-0

ATC
?

PubChem

1241

ChemSpider

1204

Informação química

Fórmula molecular

C19H21NO2 

Massa molar
295.375 g/mol

SMILES
c3ccccc3C2CN(CC=C)CCc(cc1O)c2cc1O

Farmacocinética

Biodisponibilidade
?

Metabolismo
?

Meia-vida
?

Excreção
?

Considerações terapêuticas

Administração
?

DL50		?

SKF-77,434 é um fármaco que atua como um dos agonistas parciais dopaminérgicos
D1 e tem efeitos estimulantes e anorécticos. Ao contrário doutros agonistas D1 com maior eficácia tal como o SKF-81,297 e o 6-Br-APB, o SKF-77,434 não mantém a auto-administração em estudos com animais, e tem sido estudado como uma potencial cura para o vício da cocaína.[1][2][3][4][5][6][7]



Referências



  1. ↑ Grech, D. M.; Spealman, R. D.; Bergman, J. (1996). «Self-administration of D1 receptor agonists by squirrel monkeys». Psychopharmacology. 125 (2): 97–104. PMID 8783382. doi:10.1007/BF02249407 


  2. ↑ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). «The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys». The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID 9336305 


  3. ↑ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). «Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434». The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–1026. PMID 10869406 


  4. ↑ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). «Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys». Psychopharmacology. 157 (2): 208–216. PMID 11594448. doi:10.1007/s002130100779 


  5. ↑ Mutschler, N. H.; Bergman, J. (2002). «Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys». Psychopharmacology. 160 (4): 362–370. PMID 11919663. doi:10.1007/s00213-001-0976-z 


  6. ↑ Desai, R. I.; Terry, P.; Katz, J. L. (2005). «A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice». Pharmacology, Biochemistry, and Behavior. 81 (4): 843–848. PMID 16000217. doi:10.1016/j.pbb.2005.06.006 


  7. ↑ Katz, J. L.; Kopajtic, T. A.; Terry, P. (2006). «Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats». Behavioural Pharmacology. 17 (4): 303–309. PMID 16914948. doi:10.1097/01.fbp.0000205015.67079.f7 








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