Proteína ligante de cálcio Referências Ligações externas | Menu de navegação«Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability»19433894301710.1073/pnas.93.24.13808Calcium-Binding+Proteins

Proteínas


proteinaseucarióticoscalmodulinaretículo sarcoplasmáticocalsequestrinatransdução de sinalcaexcitinaneuróniocanal de potássio dependente de voltagem




Proteína ligante de cálcio são proteinas que participam em vias de sinalização celular em que ocorre a ligação a Ca2+.


A mais comum proteína deste tipo, existente em todos os organismos eucarióticos, é a calmodulina.


O armazenamento intra-celular e a libertação de Ca2+ do retículo sarcoplasmático é associado à alta capacidade, baixa afinidade, da proteína ligante de cálcio, calsequestrina.[1]


Com a sua função na transdução de sinal, estas proteínas contribuem para muitos aspectos do funcinamento celular, desde a homeostase, à aprendizagem e memória.


Por exemplo, a caexcitina específica dos neurónio, tem em efeito excitatório nestas estruturas, e interage com proteínas que controlam o estado de disparo dos neurónios, como o canal de potássio dependente de voltagem.[2]



Referências



  1. ↑ Siegel, George (Ed.). Basic neurochemistry : molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X


  2. ↑ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D (1996). «Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability». PNAS. 93 (24): 13808–13. PMC 19433Acessível livremente. PMID 8943017. doi:10.1073/pnas.93.24.13808  !CS1 manut: Nomes múltiplos: lista de autores (link)



Ligações externas |



  • MeSH Calcium-Binding+Proteins

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