Carbidopa Farmacologia | Referências Menu de navegação28860-95-934359DB0019031640«The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells»11106255

!Páginas que usam predefinições depreciadasAminas biogénicasBenzenodióisHidrazinasInibidores enzimáticosAntiparkinsonianos


drogadoença de Parkinsonmetabolismoperiféricolevodopalevodopabarreira hematoencefálicainibe L-aminoácido aromático descarboxilasebiossínteseL-triptofanoserotoninaL-DOPAdopaminabarreira hematoencefálica





































Estrutura química de Carbidopa

Carbidopa ball-and-stick.png

Carbidopa
Star of life caution.svg Aviso médico


Nome IUPAC (sistemática)

(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid

Identificadores

CAS

28860-95-9

ATC
?

PubChem

34359

DrugBank

DB00190

ChemSpider

31640

Informação química

Fórmula molecular

C10H14N2O4 

Massa molar
226,229 g/mol

SMILES
O=C(O)[C@@](NN)(Cc1cc(O)c(O)cc1)C

Dados físicos

Ponto de fusão
203 °C °C

Ponto de ebulição
205 °C °C

Farmacocinética

Biodisponibilidade
?

Metabolismo
?

Meia-vida
?

Excreção
?

Considerações terapêuticas

Administração
?

DL50		?

Carbidopa (Lodosyn) é uma droga ministrada a pessoas com doença de Parkinson de maneira a inibir o metabolismo periférico da levodopa. Esta propriedade é significativa na medida em que permite uma maior proporção de levodopa periférica para atravessar a barreira hematoencefálica para efeito do sistema nervoso central



Farmacologia |


Carbidopa inibe L-aminoácido aromático descarboxilase (DOPA decarboxilase ou DDC),[1] uma enzima importante na biossíntese de L-triptofano a serotonina e na biossíntese de L-DOPA a dopamina (DA). DDC existe tanto fora do (periferia do corpo) e confinada pela barreira hematoencefálica.



Referências



  1. ↑ Gilbert JA, Frederick LM, Ames MM (novembro de 2000). «The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells». Clinical Cancer Research. 6 (11): 4365–72. PMID 11106255 








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